描述

PQ401是IGF1R阻斷劑，能抑制IGF1R自磷酸化，IC50 < 1 uM。

相關類別

信號通路 >> 蛋白酪氨酸激酶 >> IGF-1R

研究領域 >> 癌癥

參考文獻

[1]. Gable KL, Maddux BA, Penaranda C, Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther. 2006 Apr;5(4):1079-86.

[2]. Troib A, Landau D, Youngren JF, The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease. Growth Horm IGF Res. 2011 Oct;21(5):285-91.

[3]. Sanchez-Alavez M, Osborn O, Tabarean IV, Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem. 2011 Apr 29;286(17):14983-90.

[4]. Youssif C, et al. Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis. EMBO Mol Med. 2018 Jul;10(7). pii: e8403.

密度

1.4±0.1 g/cm3

沸點

426.1±45.0 °C at 760 mmHg

分子式

C18H16ClN3O2

分子量

341.792

閃點

211.5±28.7 °C

質量

341.093109

PSA

63.25000

LogP

5.35

外觀性狀

white

蒸汽壓

0.0±1.0 mmHg at 25°C

折射率

1.709

儲存條件

2-8°C

水溶解性

DMSO: >10mg/mL

1-(5-Chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea

IGF-1R Inhibitor II

UNII-2N3LV83S8J

1-(5-Chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea

TCMDC-125497

N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)

Urea, N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-

PQ 401

PQ401